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In these individuals, the fractional excretion of urate approaches 150%, highlighting the predominant mechanism of tubular urate secretion in the absence of reabsorption

This impairs fatty acid (FA) oxidation, which is activated by AMPK-PPAR signaling, ultimately leading to lipid accumulation under fasting or glucose-starvation conditions

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532 However, the overexpression of SIRT1 displays protection against abnormal motor function, cortical and striatal atrophy and loss of striatal neurons in the transgenic HD mice via regulating mitochondrial function